International Review of Ophthalmology

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Research progress on zebrafish model of diabetic retinopathy

Li Lele1, Zhu Manhui2, Tu Yuanyuan2, Yang Kaiwen3, Liu Dong4, Shi Yunwei4, Sang Aimin1   

  1. 1 Department of Ophthalmology, the Affiliated Hospital of Nantong University, Nantong 226000, China; 2 Lixiang Eye Hospital of Soochow University, Suzhou 215008, China; 3 Nantong University Xinglin College, Nantong 226000, China; 4 Jiangsu Key Laboratory of Neuroregeneration,  Nantong University, Nantong 226000, China
  • Received:2019-08-03 Online:2020-02-22 Published:2020-02-27
  • Contact: Sang Aimin, Email： sangam@ntu.edu.cn E-mail:sangam@ntu.edu.cn
  • Supported by:
    Jiangsu Province Graduate Research and Practice Innovation Plan（CJCX180829）

Abstract: Diabetic retinopathy (DR) is the most important manifestation of diabetic microangiopathy. It is a kind of fundus lesion with specific changes, one of the serious complications of diabetes. The specific pathogenesis of DR remains unclear, and there are no effective treatments. As a model animal, zebrafish can well simulate the pathogenesis of diabetes and DR through certain treatments. Some scholars have found that zebrafish can simulate early fundus aneurismlike changes in DR. At the same time, zebrafish can also provide a reliable reference for the therapeutic effects of newly developed drugs.